An example of the good physics that this movie shows is the artificial gravity. The artificial gravity acts as a normal force. When an object follows a circular path, there must be a force pulling it into the center, otherwise it would just go in a straight line. They achieve this by spinning the spaceship, forcing the passengers to the outside, which simulates gravity.
An example of bad physics would be the men standing on the moon. They look as if the moon has the same force of gravity as the earth. We know that because of it's size, the moon has about 6 times less gravity than the earth. The men walking towards the obelisk would have been bouncing around rather than walking regularly.
Another thing Kubrick does pay attention to is the fact that no sound can be transmitted though space. Space is a vacuum, and sound waves need particles to bounce off of in order to produce a sound wave to hit our eardrums. In each scene, there are no noises except for Dave's talking over a radio or him breathing in his suit.
This film is loved by many, but it was way to slow and boring to even be able to follow the plot, if it even had one.